3-CHYMOTRYPSIN-LIKE PROTEASE (3CLPRO) OF SARS-COV-2: VALIDATION AS A MOLECULAR TARGET, PROPOSAL OF A NOVEL CATALYTIC MECHANISM, AND INHIBITORS IN PRECLINICAL AND CLINICAL TRIALS

Proteases represent common targets in combating infectious diseases, including COVID-19.The 3-chymotrypsin-like protease (3CLpro) is a validated molecular target for COVID-19, and it is key for developing potent and selective inhibitors for inhibiting viral replication of SARS-CoV-2.In this review, we discuss structural relationships and diverse su

Penulisan artikel ini bertujuan untuk menyelesaikan permasalahan Vehicle Routing Problem with Time Windows (VRPTW) dengan menggunakan Hybrid Crow Search Algorithm (CSA) dengan Simulated Annealing (SA).Hybrid CSA dengan SA adalah gabungan dari kedua algoritma dengan cara melakukan proses CSA kemudian hasil terburuknya diperbaiki dengan proses SA unt

Isis Gayed,1 Vivian Salama,2 Lydia Dawood,1 Steven Canfield,3 David Wan,1 Chunyan Cai,4 Usha Joseph,1 Robert Amato5 1Nuclear Medicine Section, Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, 2Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center, 3Division of

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